Prediction of Hot Spots by Using Structural Neighborhood Properties

PredHS About


PredHS is a webserver which uses optimally structural neighborhood properties to effectively predict hot spots on protein-protein interaction interfaces.

Current Version

* Current Version Number: 1.0.5
* Release Date of Current Version: 4/22/2014

Contact Info

E-mail:leideng(at), jhguan(at) and sgzhou(at)


[1].   Deng L, Zhang QC, Chen Z, Meng Y, Guan J and Zhou S. PredHS: a web server for predicting protein–protein interaction hot spots by using structural neighborhood properties. Nucleic Acids Research, 42(W1):W290-W295 (2014) [PubMed]
[2].   Deng L, Guan J, Wei X, Yi Y, Zhang QC and Zhou S. Boosting Prediction Performance of Protein–Protein Interaction Hot Spots by Using Structural Neighborhood Properties. Journal of Computational Biology, 20(11):878–891 (2013) (Presented at RECOMB 2013)[PubMed]
[3].   H Wang, C Liu, L Deng. Enhanced prediction of hot spots at protein-protein interfaces using extreme gradient boosting. Scientific reports, 8 (1):14285 (2018) [PubMed]